Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome

  title={Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome},
  author={Mikayla A. Borton and Anice Sabag-Daigle and Jikang Wu and Lindsey M. Solden and Bridget S. O’Banion and Rebecca A. Daly and Richard A. Wolfe and Juan Felipe Gonzalez and Vicki H. Wysocki and Brian M M Ahmer and Kelly C. Wrighton},
BACKGROUND Salmonella is one of the most significant food-borne pathogens to affect humans and agriculture. While it is well documented that Salmonella infection triggers host inflammation, the impacts on the gut environment are largely unknown. A CBA/J mouse model was used to evaluate intestinal responses to Salmonella-induced inflammation. In parallel, we evaluated chemically induced inflammation by dextran sodium sulfate (DSS) and a non-inflammation control. We profiled gut microbial… CONTINUE READING
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