Chemical and medicobiological properties of chaga (review)

  title={Chemical and medicobiological properties of chaga (review)},
  author={M. Ya. Shashkina and Pavel N. Shashkin and Alexander V. Sergeev},
  journal={Pharmaceutical Chemistry Journal},
Data on the chemical composition and pharmacological activity of chaga (Inonotus obliquus) are reviewed. The possible mechanisms of action and factors responsible for the discrepancy of data available in the literature are discussed. The physical and chemical characteristics of melanin (polyphenolic chromogenic humin-like complex present in chaga) and its role in the regulation of physiological processes are considered. 


A review of previously published literature about this fungus is made, dealing with its ethnomycological, nutritional, pharmacological and medical aspects.

The pharmacological potential and possible molecular mechanisms of action of Inonotus obliquus from preclinical studies

This review summarizes the relevant findings with reference to the therapeutic potential of this mushroom in countering the progression of cancers, diabetes mellitus, and antiviral activities, while highlighting its possible molecular mechanisms of action.

Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga).

The antioxidant activity of hot water extract of Chaga was precisely compared with those of other medicinal fungi showing Chaga had the strongest antioxidant activity among fungi examined in terms of both superoxide and hydroxyl radicals scavenging activities.

Inonotus obliquus – from folk medicine to clinical use


A term combining the words “nutrition” and “pharmac eutical,” is a food or food product that provides health and medical benefits, including the preventi on and treatment of diseases. They have shown

Medicinal Mushrooms with Antiallergic Activities

The chapter gives an overview about mushrooms with anti-allergic activities and describes the challenges for the exploration of the antiallergic potential of mushrooms.

The Anti-Inflammatory Properties of Chaga Extracts Obtained by Different Extraction Methods against LPS-Induced RAW 264.7

Chaga, a sclerotia formed by the Inonotus obliquus fungus, has been widely recognized for a number of medicinal properties. Although numerous scientific investigations have been published describing

Hepatoprotective Effect of Inonotus obliquus Melanins: In Vitro and In Vivo Studies

It was shown that melanin produces a hepatoprotective effect which is expressed in the minimization of liver injury signs such as steatosis, necrosis, fat accumulation, and normalization of the total and unconjugated bilirubin, total protein, serum cholinesterase, and gamma-glutamyl transpeptidase levels.

The Anticancer Effect of Inonotus obliquus Pilat (Chaga) Processed by Nanomill Technology In vivo

Feeding of superfine Chaga produced by nanomill technique has a tumor growth inhibitory effect in vivo, and both groups did not show any morphological and pathological changes in the small and large intestine under the light microscope.

Chemical composition and antitumor activity of polysaccharide from Inonotus obliquus

It was found that AIOPA remarkably enhanced spleen and thymus index in mice bearing S180 sarcoma, and also stimulated LPS-induced splenocyte proliferation and the antitumor activity of AIOPA may be associated with its potent immunostimulating effect.



Biologically active compounds from Aphyllophorales (polypore) fungi.

This review describes biologically active natural products isolated from Aphyllophorales, many of which are known as polypores. Polypores are a large group of terrestrial fungi of the phylum

Brain acetylcholinesterase and its molecular forms in a precocial murid, Acomys cahirinus, and rat during post-natal development.

Brain acetylcholinesterase (AChE) and its molecular forms of a precocial murid, Acomys cahirinus, characterized by a large hippocampus, were measured during post-natal development and compared with

Lazovskaya, Chaga and Its Use for the Treatment of Stage IV Cancer [in Russian

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Chaga and Its Use for the Treatment of Stage IV Cancer [in Russian

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Biochemistry of the natural pigments.

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Reading is a need and a hobby at once and this condition is the on that will make you feel that you must read.

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  • Acad . Sci . USSR , Moscow – Leningrad

Chaga and Its Use for the Treatment of Stage IV Cancer [in Russian], Medgiz

  • Leningrad
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