Chemical and mechanistic approaches to the study of protein tyrosine phosphatases.

Abstract

Protein tyrosine phosphatases (PTPs) are signaling enzymes that control a diverse array of cellular processes. Site-directed mutagenesis, combined with detailed kinetic and mechanistic studies of Yersinia PTP, have contributed greatly to the understanding of the chemical mechanism for PTP catalysis, the nature of the enzymatic transition state, and the… (More)

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