Chemical and genomic evolution of enzyme‐catalyzed reaction networks

@article{Kanehisa2013ChemicalAG,
  title={Chemical and genomic evolution of enzyme‐catalyzed reaction networks},
  author={Minoru Kanehisa},
  journal={FEBS Letters},
  year={2013},
  volume={587}
}
There is a tendency that a unit of enzyme genes in an operon‐like structure in the prokaryotic genome encodes enzymes that catalyze a series of consecutive reactions in a metabolic pathway. Our recent analysis shows that this and other genomic units correspond to chemical units reflecting chemical logic of organic reactions. From all known metabolic pathways in the KEGG database we identified chemical units, called reaction modules, as the conserved sequences of chemical structure… Expand

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