Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts.

  title={Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts.},
  author={Ling-Jen Chen and Leo T. Burka},
  journal={Chemical research in toxicology},
  volume={20 12},
Furosemide (Lasix) is frequently used in the treatment of cardiovascular and renal disease. Only one metabolite, furosemide glucuronide, has ever been identified. Oxidation of furosemide by cytochrome P450 has been demonstrated, but the metabolite(s) has never been identified. The oxidation of furosemide by dimethyldioxirane in acetone and by liver microsomal incubations was explored in this study. The first observable product from dimethyldioxirane oxidation was a ring-expanded enone resulting… 

Electrochemical oxidation of loop diuretic furosemide in aqueous acid medium and its analytical application

Abstract An investigation of oxidative–reductive mechanisms of pharmaceutically important molecules gives us information about the metabolic fact of targeted drug. As compared to recent ongoing,

Microbial biotransformation of furosemide for environmental risk assessment: identification of metabolites and toxicological evaluation

It is demonstrated that biotic environmental transformation products may present a higher environmental risk than the starting drug, hence highlighting the importance of boosting toxicological risk assessment related to the impact of pharmaceutical waste.

Reactive metabolites in the biotransformation of molecules containing a furan ring.

  • L. Peterson
  • Chemistry, Biology
    Chemical research in toxicology
  • 2013
GSH plays an important role in modulating the harmful effects of this class of compound by reacting with the reactive metabolite, however, this may not represent a detoxification step in all cases.

Isolation and Characterization of an Unknown Process-Related Impurity in Furosemide and Validation of a New HPLC Method

Furosemide is a widely used loop diuretic in the treatment of congestive heart failure and edema. During the preparation of furosemide, a new process-related impurity G in the levels ranging from

Rearrangement reactions catalyzed by cytochrome P450s.

Dioxirane Oxidations of Compounds other than Alkenes

Epoxidations, heteroatom oxidations, and Y-H insertions constitute the best investigated oxidations by dioxiranes. This article concerns epoxidation of the double bonds in the cumulenes, such as