Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts.

@article{Chen2007ChemicalAE,
  title={Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts.},
  author={Ling-Jen Chen and Leo T. Burka},
  journal={Chemical research in toxicology},
  year={2007},
  volume={20 12},
  pages={
          1741-4
        }
}
Furosemide (Lasix) is frequently used in the treatment of cardiovascular and renal disease. Only one metabolite, furosemide glucuronide, has ever been identified. Oxidation of furosemide by cytochrome P450 has been demonstrated, but the metabolite(s) has never been identified. The oxidation of furosemide by dimethyldioxirane in acetone and by liver microsomal incubations was explored in this study. The first observable product from dimethyldioxirane oxidation was a ring-expanded enone resulting… 
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23 Citations
Background Citations
8
Methods Citations
1

23 Citations

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Reactive metabolites in the biotransformation of molecules containing a furan ring.

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Furosemide is a widely used loop diuretic in the treatment of congestive heart failure and edema. During the preparation of furosemide, a new process-related impurity G in the levels ranging from…

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Epoxidations, heteroatom oxidations, and Y-H insertions constitute the best investigated oxidations by dioxiranes. This article concerns epoxidation of the double bonds in the cumulenes, such as…