Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp. montana.

@article{Karangwa2006ChemicalAB,
  title={Chemical and biological investigations of a toxic plant from Central Africa, Magnistipula butayei subsp. montana.},
  author={C. Karangwa and V. Esters and M. Fr{\'e}d{\'e}rich and M. Tits and J. Kadima and J. Damas and A. Noirfalise and L. Angenot},
  journal={Journal of ethnopharmacology},
  year={2006},
  volume={103 3},
  pages={
          433-8
        }
}
  • C. Karangwa, V. Esters, +5 authors L. Angenot
  • Published 2006
  • Medicine, Biology
  • Journal of ethnopharmacology
  • Magnistipula butayei subsp. montana (Chrysobalanaceae) is known, in the Great Lakes Region, to possess toxicological properties. In this paper, we investigated the acute toxicity (dose levels 50-1600 mg/kg) of its aqueous extract, administered orally to adult Wistar rats. This study demonstrated that the freeze-dried aqueous extract (5%, w/w) possesses high toxicity. The extract caused hypothermia, neurological disorders, including extensor reflex of maximal convulsive induced-seizures at about… CONTINUE READING
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