Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.

@article{Ghosh2009ChemicalAB,
  title={Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.},
  author={Nandita Ghosh and H. Sheldrake and M. Searcey and K. Pors},
  journal={Current topics in medicinal chemistry},
  year={2009},
  volume={9 16},
  pages={
          1494-524
        }
}
CC-1065, the duocarmycins and yatakemycin are members of a family of ultrapotent antitumour antibiotics that have been the subject of extensive investigations due to their mode of action and potential in the design of new anticancer therapeutics. The natural products and their analogues exert their effects through a sequence selective alkylation of duplex DNA in the minor groove at the N3 of adenine. An understanding of their structure and its effect on biological activity has been derived… Expand
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Characterization of a representative O-(acylamino) prodrug in vivo indicates that they approach the potency and exceed the efficacy of thefree drug itself (CBI-indole2), indicating that not only is the free drug effectively released from the inactive prodrug but also that they offer additional advantages related to a controlled or targeted release in vivo. Expand
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