Chemical and biological evolution of a nucleotide-binding protein

@article{Rossmann1974ChemicalAB,
  title={Chemical and biological evolution of a nucleotide-binding protein},
  author={Michael G. Rossmann and Dino Moras and Kenneth W Olsen},
  journal={Nature},
  year={1974},
  volume={250},
  pages={194-199}
}
Three-dimensional alignment of the common nucleotide binding structure in dehydrogenases, kinases and flavodoxins permits the recognition of homologous amino acids when sequence comparisons alone would fail. Minimum base changes per codon can then be used to measure evolutionary distances which suggest that this structure was present during precellular evolution. 
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