Chemical and Biological Applications of Digital-Microfluidic Devices

  title={Chemical and Biological Applications of Digital-Microfluidic Devices},
  author={Richard B. Fair and Andrey Y. Khlystov and Tina D. Tailor and Vladislav Ivanov and R. Evans and Vijay Srinivasan and Vamsee K. Pamula and Michael G. Pollack and Peter B. Griffin and Jack G. Zhou},
  journal={IEEE Design \& Test of Computers},
Digital-microfluidic lab-on-a chip (LoC) technology offers a platform for developing diagnostic applications with the advantages of portability, sample and reagent volume reduction, faster analysis, increased automation, low power consumption, compatibility with mass manufacturing, and high throughput. In addition to diagnostics, digital microfluidics is finding use in airborne chemical detection, DNA sequencing by synthesis, and tissue engineering. In this article, we review efforts to develop… 

Digital microfluidics technologies for biomedical devices

Abstract: Droplet-based digital microfluidics is a topic with growing relevance to biological, chemical, and health-science fields. The high precision and excellent reagent economy of such systems

Algorithmic Challenges in Digital Microfluidic Biochips: Protocols, Design, and Test

This review article will elaborate on several algorithmic challenges that arise while realizing biochemical protocols on a digital microfluidic lab-on-a-chip, and focus on certain design automation issues of sample preparation, dilution gradient generation, layout planning, and testing of DMF biochips.

Dynamic sampling in digital microfluidic devices

There are critical implementation challenges to consider for new digital microfluidic technologies. In dynamic applications, properties of both the system and the microdroplet are changing in time

Design Tools for Digital Microfluidic Biochips: Toward Functional Diversification and More Than Moore

The droplet-based “digital” microfluidic technology platform and emerging applications are described, and computer-aided design tools for simulation, synthesis and chip optimization are presented.

Programmable Hybrid Integrated Circuit/Microfluidic Chips

This work reviews work done by the group to develop hybrid IC/microfluidic chips that can simultaneously control thousands of living cells and picoliter volumes of fluid, enabling a wide variety of chemical and biological tasks.

Digital microfluidics.

This review summarizes the state of the art of DMF technology from the perspective of analytical chemistry in sections describing the theory of droplet actuation, device fabrication and integration, and applications.

Digital Microfluidic Cell Culture.

The state-of-the-art in DMF cell culture is summarized, design considerations, types of DMFcell culture, and cell-based applications ofDMF are described.

A review of digital microfluidics as portable platforms for lab-on a-chip applications.

The most recent advances in the DMF platforms are discussed, and the feasibility of developing multifunctional packages for performing complete sets of processes of biochemical assays, particularly for point-of-care applications is evaluated.

Digital microfluidic biochips: A vision for functional diversity and more than moore

  • K. Chakrabarty
  • Chemistry, Biology
    2010 IEEE/ACM International Conference on Computer-Aided Design (ICCAD)
  • 2010
This tutorial paper provides an overview of DMFBs and describes emerging computer-aided design (CAD) tools for the automated synthesis and optimization of biochips, from physical modeling to fluidic-level synthesis and then to chip-level design.

Design Automation and Test Solutions for Digital Microfluidic Biochips

  • K. Chakrabarty
  • Biology
    IEEE Transactions on Circuits and Systems I: Regular Papers
  • 2010
This tutorial paper describes emerging computer-aided design (CAD) tools for the automated synthesis and optimization of biochips from bioassay protocols and recent advances in fluidic-operation scheduling, module placement, droplet routing, pin-constrained chip design, and testing are presented.



Integrated chemical/biochemical sample collection, pre-concentration, and analysis on a digital microfluidic lab-on-a-chip platform

An ideal on-site chemical/biochemical analysis system must be inexpensive, sensitive, fully automated and integrated, reliable, and compatible with a broad range of samples. The advent of digital

Rapid droplet mixers for digital microfluidic systems.

This paper studies the effects of varying droplet aspect ratios on linear-array droplet mixers, and proposes mixing strategies applicable for both high and low aspect ratio systems, and presents a split-and-merge mixer that takes advantage of the ability to perform droplet splitting at these ratios.

Droplet-based chemistry on a programmable micro-chip.

A long-term goal of this research is to provide a platform fluidic processor technology that can form the core of versatile, automated, micro-scale devices to perform chemical and biological assays at or near the point of care, which will increase the availability of modern medicine to people who do not have ready access to modern medical institutions, and decrease the cost and delays associated with that lack of access.

Droplet-based microfluidics with nonaqueous solvents and solutions.

It is shown for the first time that it is possible to manipulate droplets of organic solvents, ionic liquids, and aqueous surfactant solutions in air by these mechanisms using only modest voltages and frequencies.

Electrowetting-based actuation of droplets for integrated microfluidics.

An alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported, providing a means to achieve high levels of functional integration and flexibility formicrofluidic systems.

Electrowetting-based droplet mixers for microfluidic systems.

This work presents an alternative mixing strategy based on the discretization of liquids into droplets and further manipulation of those droplets by electrowetting that can be dynamically reconfigured to any location on the chip to improve the throughput of the lab-on-a-chip.

Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits

Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl

Electrowetting-based actuation of liquid droplets for microfluidic applications

A microactuator for rapid manipulation of discrete microdroplets is presented. Microactuation is accomplished by direct electrical control of the surface tension through two sets of opposing planar