Chemical and Biological Applications of Digital-Microfluidic Devices

@article{Fair2007ChemicalAB,
  title={Chemical and Biological Applications of Digital-Microfluidic Devices},
  author={Richard B. Fair and Andrey Y. Khlystov and Tina D. Tailor and Vladislav Ivanov and R. Evans and Vijay Srinivasan and Vamsee K. Pamula and Michael G. Pollack and Peter B. Griffin and Jack G. Zhou},
  journal={IEEE Design \& Test of Computers},
  year={2007},
  volume={24}
}
Digital-microfluidic lab-on-a chip (LoC) technology offers a platform for developing diagnostic applications with the advantages of portability, sample and reagent volume reduction, faster analysis, increased automation, low power consumption, compatibility with mass manufacturing, and high throughput. In addition to diagnostics, digital microfluidics is finding use in airborne chemical detection, DNA sequencing by synthesis, and tissue engineering. In this article, we review efforts to develop… Expand
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References

SHOWING 1-10 OF 59 REFERENCES
Integrated chemical/biochemical sample collection, pre-concentration, and analysis on a digital microfluidic lab-on-a-chip platform
An ideal on-site chemical/biochemical analysis system must be inexpensive, sensitive, fully automated and integrated, reliable, and compatible with a broad range of samples. The advent of digital… Expand
Droplet-based microfluidic lab-on-a-chip for glucose detection
Abstract A microfluidic lab-on-a-chip (LoC) platform for in vitro measurement of glucose for clinical diagnostic applications is presented in this paper. The LoC uses a discrete droplet format in… Expand
Rapid droplet mixers for digital microfluidic systems.
TLDR
This paper studies the effects of varying droplet aspect ratios on linear-array droplet mixers, and proposes mixing strategies applicable for both high and low aspect ratio systems, and presents a split-and-merge mixer that takes advantage of the ability to perform droplet splitting at these ratios. Expand
Droplet-based chemistry on a programmable micro-chip.
TLDR
A long-term goal of this research is to provide a platform fluidic processor technology that can form the core of versatile, automated, micro-scale devices to perform chemical and biological assays at or near the point of care, which will increase the availability of modern medicine to people who do not have ready access to modern medical institutions, and decrease the cost and delays associated with that lack of access. Expand
Microfluidic devices for DNA sequencing: sample preparation and electrophoretic analysis.
Modern DNA sequencing 'factories' have revolutionized biology by completing the human genome sequence, but in the race to completion we are left with inefficient, cumbersome, and costly macroscale… Expand
Droplet-based microfluidics with nonaqueous solvents and solutions.
TLDR
It is shown for the first time that it is possible to manipulate droplets of organic solvents, ionic liquids, and aqueous surfactant solutions in air by these mechanisms using only modest voltages and frequencies. Expand
Electrowetting-based actuation of droplets for integrated microfluidics.
TLDR
An alternative approach to microfluidics based upon the micromanipulation of discrete droplets of aqueous electrolyte by electrowetting is reported, providing a means to achieve high levels of functional integration and flexibility formicrofluidic systems. Expand
Electrowetting-based droplet mixers for microfluidic systems.
TLDR
This work presents an alternative mixing strategy based on the discretization of liquids into droplets and further manipulation of those droplets by electrowetting that can be dynamically reconfigured to any location on the chip to improve the throughput of the lab-on-a-chip. Expand
Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits
Reports the completion of four fundamental fluidic operations considered essential to build digital microfluidic circuits, which can be used for lab-on-a-chip or micro total analysis system (/spl… Expand
Electrowetting-based actuation of liquid droplets for microfluidic applications
A microactuator for rapid manipulation of discrete microdroplets is presented. Microactuation is accomplished by direct electrical control of the surface tension through two sets of opposing planar… Expand
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