Chemical analysis of two new designer drugs: buphedrone and pentedrone.

  title={Chemical analysis of two new designer drugs: buphedrone and pentedrone.},
  author={Chad R. Maheux and Catherine R. Copeland},
  journal={Drug testing and analysis},
  volume={4 1},
The hydrochloride salts of buphedrone and pentedrone, two new designer drugs, have recently been identified in shipments destined for Canada. To confirm their identities, we have synthesized reference materials for these methcathinone analogues and herein provide complete characterization by FTIR, FT-Raman, ¹H NMR, ¹³C NMR, GC/MS and ESI-HRMS. 

Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS.

  • J. CarrolaN. Duarte M. Bronze
  • Chemistry, Biology
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2020

Analytical characterization of three cathinone derivatives, 4-MPD, 4F-PHP and bk-EPDP, purchased as bulk powder from online vendors.

Novel emerging drugs of abuse, also referred as new psychoactive substances, constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical

Metabolite Structure Assignment of Seized Products Containing Cathinone Derivatives through High Resolution Analytical Techniques

The innovation of the new psychoactive substances (NPS) market requires the rapid identification of new substances that can be a risk to public health, in order to reduce the damage due to their use.

Identification of polymorphism in ethylone hydrochloride: synthesis and characterization

This report, alongside the recent article on the single crystal X‐ray structure of a second polymorph of this synthetic cathinone, is the first to confirm polymorphism in ethylone hydrochloride.

Structure Assignment of Seized Products Containing Cathinone Derivatives Using High Resolution Analytical Techniques

Among the adulterants found in these samples, caffeine was the most frequently detected substance, followed by ethylphenidate, which highlights the prevalence of SCat in seized materials of the Portuguese market.



Some new psychoactive substances: precursor chemicals and synthesis-driven end-products.

A link between synthetic approaches published in the open scientific and medical literature and the exploitation of this research by clandestine manufacture of drugs for illicit purposes is drawn.

Characterization of Three Methcathinone Analogs: 4-Methylmethcathinone, Methylone, and bk-MBDB

Complete spectroscopic characterization (FTIR, FT-Raman, 1 H NMR, 13 C NMR, GC/MS, and EI-HRMS) is presented for the hydrochloride salts of 3,4-methylenedioxymethcathinone (methylone),

Mass spectral and NMR spectral data of two new designer drugs with an alpha-aminophenone structure: 4'-methyl-alpha-pyrrolidinohexanophenone and 4'-methyl-alpha-pyrrolidinobutyrophenone.

The structure elucidation of the aliphatic part of MPBP was carried out by product ion spectroscopy of the immonium ion formed after electron ionization as well as with 1H and 13C NMR.

Reference materials for new psychoactive substances.

The need for collaboration at all levels is highlighted as essential to rapid identification of requirements for new reference materials, as well as use of alternative sources, including pharmaceutical impurity materials or internet sourced products, as starting materials for conversion into appropriately certified reference materials.

An overview of new psychoactive substances and the outlets supplying them.

Availability of new psychoactive substances • The number of head shops in Ireland has been decreasing significantly on foot of actions taken by the Government to restrict and control new

Analyses of second-generation 'legal highs' in the UK: initial findings.

It was found that 70% of NRG-1 andNRG-2 products appeared to contain a mixture of cathinones banned in April 2010 and rebranded as 'new' legal highs, rather than legal chemicals such as naphyrone as claimed by the retailers.

An analysis of legal highs: do they contain what it says on the tin?

Six out of 7 legal-high products purchased and analyzed for their content did not contain the advertised active ingredient and five samples contained the controlled substances benzylpiperazine and 1-[3-(trifluoromethyl)phenyl]p Piperazine combined with caffeine.