Chemical agents that promote chromatin compaction radiosensitize tumour cells.

@article{Biade2001ChemicalAT,
  title={Chemical agents that promote chromatin compaction radiosensitize tumour cells.},
  author={Siham Biade and Corinne C Stobbe and Jonathan T. Boyd and J. Donald Chapman},
  journal={International journal of radiation biology},
  year={2001},
  volume={77 10},
  pages={1033-42}
}
PURPOSE Previous studies indicated that cells whose chromatin is naturally compacted at the time of radiation are hypersensitive to radiation-induced killing, primarily by single-hit inactivation. Some chemicals that are known to promote chromatin compaction in interphase cells are here investigated for their radiosensitizing potential. MATERIALS AND METHODS Okadaic acid (OA), a protein phosphatase inhibitor, fostriecin (FC), a topoisomerase II inhibitor and trichostatin A (TSA), a histone… CONTINUE READING

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