Chemical activation of thin-fiber phrenic afferents: respiratory responses.

  title={Chemical activation of thin-fiber phrenic afferents: respiratory responses.},
  author={Sabah N. A. Hussain and Sheldon A. Magder and A C Chatillon and Ch. Roussos},
  journal={Journal of applied physiology},
  volume={69 3},
In supine chloralose-anesthetized and mechanically ventilated dogs, we assessed the effects of group III and IV thin-fiber phrenic afferents on cardiorespiratory control by injecting capsaicin into the phrenic artery of an in situ isolated and innervated left diaphragm. Inspiratory motor drive was assessed by measuring the electromyogram of left and right diaphragm, left parasternal, and mylohyoid muscles in five protocols. 1) Three boluses (2 ml) of capsaicin (1, 10, and 50 micrograms/ml) were… CONTINUE READING

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