Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration

@inproceedings{Cuervo2013ChemicalAO,
  title={Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration},
  author={Rodrigo Cuervo and Jes{\'u}s Chimal-Monroy},
  booktitle={Scientific reports},
  year={2013}
}
The anuran amphibian Xenopus laevis can regenerate its limbs for a limited time during the larval stage, while limbs are still developing. Using this regeneration model, we evaluated the proximo-distal blastema cell identity when endogenous retinoids were increased by CYP26 inhibition or when RAR-specific agonists altered RA signaling. Simultaneous proximo-distal and antero-posterior limb duplications were generated, and the RAR-specific agonist can modify blastema identity after amputation… CONTINUE READING
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