Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies.

Abstract

The development of carbohydrate-based antitumor vaccines is an attractive approach towards tumor prevention and treatment. Herein, we focused on the ganglioside GM2 tumor-associated carbohydrate antigen (TACA), which is overexpressed in a wide range of tumor cells. GM2 was synthesized chemically and conjugated with a virus-like particle derived from… (More)
DOI: 10.1002/cbic.201500499

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@article{Yin2016ChemicalSO, title={Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ, and the Induction of Anticancer Antibodies.}, author={Zhaojun Yin and Steven B Dulaney and Craig S. McKay and Claire Baniel and Katarzyna Kaczanowska and Sherif Ramadan and M G Finn and Xuefei Huang}, journal={Chembiochem : a European journal of chemical biology}, year={2016}, volume={17 2}, pages={174-80} }