• DOI:10.18483/IJSCI.1261
• Corpus ID: 73586166

Chemical Screening, Acute Toxicity and Analgesic Effect of the Aqueous Extracts of Vitex madiensis Oliv. (Lamiaceae-Viticoïdeae) and Phytolacca dodecandra L’Hérit. (Phytolaccaceae) Leaves

@article{Gf2018ChemicalSA,
  title={Chemical Screening, Acute Toxicity and Analgesic Effect of the Aqueous Extracts of Vitex madiensis Oliv. (Lamiaceae-Vitico{\"i}deae) and Phytolacca dodecandra L’H{\'e}rit. (Phytolaccaceae) Leaves},
  author={Nsonde Ntandou Gf and N’Goka and Boumba Sl and Abena Aa},
  journal={International journal of sciences},
  year={2018},
  volume={4},
  pages={1-9}
}

• Nsonde Ntandou Gf, N’Goka, +1 author Abena Aa
• Published 5 February 2018
• Biology
• International journal of sciences

The purpose of this study is to identify the various secondary metabolites and evaluate the toxicity and analgesic activity of Vitex madiensis Oliv.(VM) and Phytolacca dodecandra L’Herit.(PD) aqueous extracts two plants used in traditional medicine in Congo for the management of pain and other conditions. Phytochemical analysis ,by using tube reaction method, revealed very strong presence of saponins, strong presence of alkaloids and tannins from PD; strong presence of tannins, sterols and tri-terpenes from VM. Standard procedures using OECD Guideline helped to consider the VM extract non-toxic with an LD50 greater than 5000 mg / kg and the PD extract low toxic with an LD50 greater than 2000 g / kg in mice. Extracts promote an increase in body mass. Extracts tested at the doses of 50, 100 and 200 mg / kg inhibit significantly (p <0.001) the abdominal cramps induced by acetic acid in mice. PD extract was more effective. Extracts decrease significantly (P <0.001) the pain in the first phase (200 mg/kg) and second phase (50, 100 and 200 mg/kg) on formalin test.The signs of toxicity with PD extract and the inhibition of pain by both extracts would be due to the secondary metabolites presents in these extracts. The results obtained suggest that the analgesic effect of VM and PD may be mediated via both central and peripheral mechanisms.