Chemical Profiles and Simultaneous Quantification of Aurantii fructus by Use of HPLC-Q-TOF-MS Combined with GC-MS and HPLC Methods

@article{He2018ChemicalPA,
  title={Chemical Profiles and Simultaneous Quantification of Aurantii fructus by Use of HPLC-Q-TOF-MS Combined with GC-MS and HPLC Methods},
  author={Yingjie He and Zongkai Li and Wei Wang and Suren R Sooranna and Yiting Shi and Yun Chen and Changqiao Wu and Jianguo Zeng and Qi Tang and Hongqi Xie},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2018},
  volume={23}
}
  • Yingjie He, Zongkai Li, Hongqi Xie
  • Published 30 August 2018
  • Medicine, Chemistry
  • Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Aurantii fructus (AF) is a traditional Chinese medicine that has been used to improve gastrointestinal motility disorders for over a thousand years, but there is no exhaustive identification of the basic chemical components and comprehensive quality control of this herb. In this study, high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (HPLC-Q-TOF-MS) and gas chromatography coupled mass spectrometry (GC-MS) were employed to identify the basic… 

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References

SHOWING 1-10 OF 50 REFERENCES
Identification of flavonoid metabolites of Fructus Aurantii Immaturus in rat biological samples by liquid chromatography-tandem mass spectrometry.
High-performance liquid chromatography with tandem mass spectrometry(HPLC-MS/MS) was used for separation and identification of flavonoid metabolites in rat urine,feces and bile after oral
Identification of chemical constituents in extracts and rat plasma from Fructus Aurantii by UPLC-PDA-Q-TOF/MS.
TLDR
An ultra-performance liquid chromatography-photodiode array detector-quadrupole time-of-flight mass spectrometry method was established and has proved useful in the study of the active constituents in traditional Chinese medicines.
Rapid Investigation and Screening of Bioactive Components in Simo Decoction via LC-Q-TOF-MS and UF-HPLC-MD Methods
TLDR
The results indicate the systematic identification and screening of HSA ligands from Simo decoction guided by LC-Q-TOF-MS and UF-HPLC-MD represents a feasible and efficient method that could be extended for the identification and screenings of other bioactive ingredients from natural medicines.
Chemical fingerprint and metabolic profile analysis of Citrus reticulate 'Chachi' decoction by HPLC-PDA-IT-MS(n) and HPLC-Quadrupole-Orbitrap-MS method.
  • Xiao-lan Ye, Di Cao, Fuhai Wu
  • Chemistry
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2014
Systematic Analysis of Main Constituents in Rat Biological Samples after Oral Administration of the Methanol Extract of Fructus Aurantii by HPLC-ESI-MS/MS
TLDR
The identification and elucidation of parent and metabolism components analyzed in biological samples provided the data for further pharmacological and clinical research on FA.
Comparison of Aurantii Fructus Immaturus and Aurantii Fructus based on multiple chromatographic analysis and chemometrics methods.
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