• Corpus ID: 36938384

Chemical Peeling in the Treatment of Xeroderma Pigmentosum

@inproceedings{Alzacko2014ChemicalPI,
  title={Chemical Peeling in the Treatment of Xeroderma Pigmentosum},
  author={Saadallah M. Alzacko and Basil H. Abdulrazaq},
  year={2014}
}
INTRODUCTION: Xeroderma pigmentosum (XP) is an autosomalrecessive disease characterized by extreme sensitivity to sunlight, resulting in sunburn, pigment changes in the skin and a greatly elevated incidence of skin cancers. The clinical manifestations appear early in life, after the child is first exposed to the sun. Life expectancy is significantly reduced because of metastases, infection or neurologic complications (1) . Estimated incidences vary from 1 in 20, 000 in Japan to 1 in 250, 000 in… 
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References

SHOWING 1-10 OF 21 REFERENCES
Combined treatment of xeroderma pigmentosum with full-face chemical peeling and dermabrasion
TLDR
Surgical excision of the lesions followed by full-face chemical peeling and dermabrasion was accomplished in the same operative session in 11 patients, thought to provide effective prophylaxis against malignant degeneration.
Xeroderma pigmentosum
TLDR
Although there is no cure for XP, the skin effects can be minimised by rigorous protection from sunlight and early removal of pre-cancerous lesions, and the prognosis is good.
Dermatome shaving in the treatment of xeroderma pigmentosum.
In one patient with xeroderma pigmentosum, the epidermis and superficial dermis were removed from the lower legs with an electric dermatome. This retarded the development of malignant tumors, and the
Xeroderma pigmentosum. Treatment with topically applied fluorouracil.
TLDR
The treated areas of the two patients with xeroderma pigmentosum have remained free of lesions for 11 months while the untreated areas have continued to develop actinic keratoses and squamous cell carcinomas at a rate equal to the pretreatment period.
Facial resurfacing in xeroderma pigmentosum with chemical peeling.
TLDR
The experience with two patients with xeroderma pigmentosum who underwent multiple trichloroacetic acid chemical peels is described, finding chemical peeling is a simple procedure with less associated morbidity.
The risk of malignant melanoma, internal malignancy and mortality in xeroderma pigmentosum patients
TLDR
It is generally assumed that XP patients have a high mortality from actinic‐induced cutaneous tumours in the second and third decades, and previously reported studies have not given estimates of the level of age specific, and hence overall, risk of malignancy and mortality in XP.
The role of dermabrasion and chemical peels in the treatment of patients with xeroderma pigmentosum.
Facial resurfacing in xeroderma pigmentosum with monoblock full-thickness skin graft.
TLDR
The radical surgical approach advocated here has improved the prognosis in the case reported and the quality and tumor-free features of the monoblock full-thickness skin graft in xeroderma pigmentosum are indicated.
Planing for precancerous skin.
  • E. Epstein
  • Medicine
    A.M.A. archives of dermatology
  • 1956
TLDR
The difficulty of evaluating abrasion methods of treating cutaneous pathologic entities is concerned with personalities, and some of the advocates of this procedure were so enthusiastic that this modality was introduced into my therapeutic armamentarium.
Trichloroacetic Acid Peeling Versus Dermabrasion: A Histometric, Immunohistochemical, and Ultrastructural Comparison
TLDR
Beneficial effects of such modalities on facial skin were accomplished primarily by increasing the amounts of collagen I and collagen III and improving the morphologic appearance of collagen and elastic fibers.
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