Chemical Nature of Chromosomes

@article{Choudhuri1943ChemicalNO,
  title={Chemical Nature of Chromosomes},
  author={H. C. Choudhuri},
  journal={Nature},
  year={1943},
  volume={152},
  pages={475-475}
}
THE staining properties of chromosomes have hitherto been regarded as due to their content of nucleic acid. Recently, however, Stedman and Stedman1 have demonstrated the presence in animal chromosomes of a new protein, chromosomin, which they have shown not only to be the principal component of the chromosomes but also responsible for their staining properties. Part of their proof depended on the demonstration of the fact that when chromosomin, isolated from animal nuclei, is introduced into… Expand
Distribution of Nucleic Acid in the Cell
IN a recent article, Stedman and Stedman1 claim to have discovered a new protein constituent of chromosomes, termed “chromosomin”. They allege that Feulgen's reaction does not demonstrate theExpand
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The Feulgen “nucleal” reaction provides an important tool for studies concerned with the desoxypentosenucleic acid (DNA) content and distribution in normal and abnormal cells. Expand
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The results of experiments on the specificity of the Feulgen reaction for thymonucleic acid do not substantiate the observations of Carr, and important differences between these stains were found in the effects of preliminary hydrolysis; rapidity of staining and destaining; extractability of dye from tissues by water, alcohol, and sulfurous acid solution. Expand
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It is the opinion that for a procedure to qualify as a quantitative method it must be possible to state the results in absolute values so that they may be tested by independent methods (such as macrochemical analysis). Expand
Cytochemical Reactions of Nucleic Acids
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  • Medicine, Biology
  • The Quarterly Review of Biology
  • 1950
TLDR
The purpose of this paper is to review the most pertinent literature concerning the cytochemical techniques for studying the nucleic acids and to discuss their validity as specific tests. Expand
Constitution of the Salivary Gland Chrombsomes of Chironomus
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It is concluded from their X-ray diffraction and birefringence data that the most important elements in the molecular organization of the chromosomes are the partially folded and partially extended polypeptide chains, together with the parallel fitting of thy-monucleic acid on to the extended portion of the chains. Expand
Feulgen Reaction for Thymonucleic Acid
TLDR
The staining of tissues by the Feulgen reaction is compared with that of hematoxylin, basic fuchsia, and fuchsin-sulfurous-acid reagent in which the color had been developed by the addition of formaldehyde. Expand
Basic fuchsin as a nuclear stain.
Five distinct nuclear stains and staining procedures which utilize basic fuchsin as the dye have been studied, compared and tested on a Feulgen-weak fungus, Blastomyces dermatitidis, and otherExpand
The nature and specificity of the Feulgen reaction.
  • M. A. Lessler
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1951
TLDR
The appearance of color resulting from the Feulgen reaction, under properly controlled conditions, is evidence for the actual site of desoxypentose nucleoprotein complexes in the cell, indicating a departure from the ideal Beer-Lambert law. Expand
The Relative Thymonucleic Acid Content of Human Normal Epidermis, Hyperplastic Epidermis, and Epidermoid Carcinomas
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The present study on epidermoid carcinomas of human skin was undertaken to expand the observations made on mice and to determine whether the amount of thymonucleic acid in epidersmold carcinomas was greater in the more anaplastic tumors. Expand
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References

Chromosomin, a Protein Constituent of Chromosomes
ACCORDING to current views, the nuclei of the cells of animals and plants consist, apart from water and lipoids, essentially of two substances: a basic protein (protamine or histone) and nucleicExpand