Chemical Evolution of Autotaxin Inhibitors

  title={Chemical Evolution of
Autotaxin Inhibitors},
  author={Harald M. H. G. Albers and Huib Ovaa},
  booktitle={Chemical reviews},
(ATX or ENPP2) was isolated as an autocrine motility factor from melanoma cells. 1 The ∼120 kDa glycoprotein ATX belongs to a small family named ectonucleotide pyrophosphatase and phosphodiesterase (ENPP), which consists of seven family members. 2 ATX is the only ENPP family member with lysophospholipase D (lysoPLD) activity and is responsible for the hydrolysis of lysophosphatidylcholine (LPC) to produce the bioactive lipid lysophosphatidic acid (LPA) (Scheme 1). 3,4 LPA acts on specific G… CONTINUE READING