Chemical Composition and in vitro Cytotoxic and Antileishmanial Activities of Extract and Essential Oil from Leaves of Piper cernuum

@article{Capello2015ChemicalCA,
  title={Chemical Composition and in vitro Cytotoxic and Antileishmanial Activities of Extract and Essential Oil from Leaves of Piper cernuum},
  author={Tabata M. Capello and E. G. A. Martins and Camyla F de Farias and C. Figueiredo and A. Matsuo and L. F. Passero and D. Oliveira-Silva and P. Sartorelli and J. Lago},
  journal={Natural Product Communications},
  year={2015},
  volume={10}
}
Fractionation of the MeOH extract from leaves of Piper cernuum Vell. (Piperaceae) afforded six phenylpropanoid derivatives: 3′,4′-dimethoxy-dihydrocinnamic acid (1), piplaroxide (2), methyl 4′-hydroxy-3′,5′-dimethoxy cinnamate (3), 3′,4′,5′-trimethoxydihydrocinnamic acid (3), dihydropiplartine (5), and piplartine (6). The structures of isolated metabolites were characterized by NMR and MS spectral data analysis. The chemical composition of essential oil from the leaves was determined using GC… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
Chemical Constituents and Cytotoxic Evaluation of Essential Oils from Leaves of Porcelia macrocarpa (Annonaceae)
TLDR
The results suggested that the crude oils and their components, mainly germacrene D, could be used as prototypes for the development of new anti-cancer agents for the treatment of human leukemia. Expand
Essential oils from Schinus terebinthifolius leaves – chemical composition and in vitro cytotoxicity evaluation
TLDR
The obtained results indicated that the monoterpenes α- and β-pinenes could be responsible to the cytotoxic activity detected in the crude oil from leaves of S. terebinthifolius, and it was possibly inferred that the presence of double bond in their structures is crucial to cytotoxicity potential detected in these derivatives. Expand
Essential Oil from Caesalpinia peltophoroides Flowers – Chemical Composition and in vitro Cytotoxic Evaluation
The chemical composition of the essential oil obtained from the flowers of Caesalpinia peltophoroides Benth (Leguminosae) was determined using GC/FID and GC/MS analysis. Twenty-seven compounds wereExpand
Trans-β-Caryophyllene: An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.)
This study investigated the leishmanicidal activity against Leishmania amazonensis of four commercial oils from Copaifera spp. named as C1, C2, C3, and C4, the sesquiterpene and diterpene poolsExpand
Chemical and Biological Analyses of the Essential Oils and Main Constituents of Piper Species
TLDR
The HET-CAM test was used to evaluate the irritation potential of these oils as topical products, showing that these oils can be used as auxiliary medication in cases of cutaneous leishmaniasis, with less side effects and lower costs. Expand
Molluscicidal and Leishmanicidal Activity of the Leaf Essential Oil of Syzygium cumini (L.) Skeels from Brazil
TLDR
The essential oil of S. cumini showed promising activity as a molluscicidal and leishmanicidal agent and might be valuable in combating neglected tropical diseases such as schistosomiasis andLeishmaniasis. Expand
IN VITRO TRYPANOCIDAL EVALUATION OF PINANE DERIVATIVES FROM ESSENTIAL OILS OF RIPE FRUITS FROM Schinus terebinthifolius RADDI (ANACARDIACEAE)
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)-Expand
Volatile Constituents of Piperaceae from Santa Catarina, Brazil—Essential Oil Composition of Piper cernuum Vell. and Peperomia emarginella (Sw.) C. DC.
TLDR
The essential oil composition of two Piperaceae from the Itajaí Valley in Santa Catarina, Brazil, is described by means of GC and GC/MS analysis and peanut emarginella provided the most interesting oil due to its pleasant and intense odor. Expand
Intraspecific variation and cytotoxic evaluation of the essential oils from Oxandra sessiliflora R. E. Fries
For the first time, the chemical composition and cytotoxic evaluation of essential oils from leaves of Oxandra sessiliflora R. E. Fries (Annonaceae) has been reported. Leaves of O. sessiflora wereExpand
Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms.
TLDR
The results demonstrate the potentialities of EO in cellular and molecular system, which could be consider in future studies to develop new antileishmanial drugs with a wide anti-parasitic spectrum. Expand
...
1
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