Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

@inproceedings{Jones2012ChemicalGA,
  title={Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome},
  author={Deuan C. Jones and Magnus S. Alphey and Susan Wyllie and Alan H. Fairlamb},
  booktitle={Molecular microbiology},
  year={2012}
}
Pyridoxal-5'-phosphate (vitamin B(6) ) is an essential cofactor for many important enzymatic reactions such as transamination and decarboxylation. African trypanosomes are unable to synthesise vitamin B(6) de novo and rely on uptake of B(6) vitamers such as pyridoxal and pyridoxamine from their hosts, which are subsequently phosphorylated by pyridoxal kinase (PdxK). A conditional null mutant of PdxK was generated in Trypanosoma brucei bloodstream forms showing that this enzyme is essential for… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases

  • M. K. Safo, F. N. Musayev, M. L. Di Salvo, S. Hunt, J. B. Claude, V. Schirch
  • J Bacteriol
  • 2006
Highly Influential
6 Excerpts

Crystal Structure of human pyridoxal kinase: structural basis of M+ and M2+ activation

  • F. N. Musayev, M. L. Di Salvo, +4 authors M. K. Safo
  • Protein Sci
  • 2007
Highly Influential
3 Excerpts

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