Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes.

@article{Takahashi2008ChemerinEI,
  title={Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes.},
  author={Michiko Takahashi and Yutaka Takahashi and Kenichi Takahashi and Fyodor N. Zolotaryov and Kyoung Su Hong and Riko Kitazawa and Keiji Iida and Yasuhiko Okimura and Hidesuke Kaji and Sohei Kitazawa and Masato Kasuga and Kazuo Chihara},
  journal={FEBS letters},
  year={2008},
  volume={582 5},
  pages={573-8}
}
To explore a novel adipokine, we screened adipocyte differentiation-related gene and found that TIG2/chemerin was strongly induced during the adipocyte differentiation. Chemerin was secreted by the mature 3T3-L1 adipocytes and expressed abundantly in adipose tissue in vivo as recently described. Intriguingly, the expression of chemerin was differently regulated in the liver and adipose tissue in db/db mice. In addition, serum chemerin concentration was decreased in db/db mice. Chemerin and its… CONTINUE READING