Chemerin/chemR23 axis in inflammation onset and resolution

@article{Mariani2014ChemerinchemR23AI,
  title={Chemerin/chemR23 axis in inflammation onset and resolution},
  author={Francesco Mariani and Luca Roncucci},
  journal={Inflammation Research},
  year={2014},
  volume={64},
  pages={85-95}
}
Chemerin is an adipokine secreted by adipocytes and associated with obesity, insulin resistance and metabolic syndrome. Different chemerin fragments with pro- or anti-inflammatory action can be produced, depending on the class of proteases predominating in the microenvironment. Chemerin binds to three receptors, especially to chemR23, expressed on various cells, as dendritic cells, macrophages and natural killer cells, regulating chemotaxis towards the site of inflammation and activation status… CONTINUE READING

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