Chem. Pharm. Bull. 53(5) 555—560 (2005)


found in amphibian skin, and the 5,8-disubstituted indolizidines, one of the largest subclass of these alkaloids, were detected from skin extracts of the poison-frog. Quite recently, we have found the synthetic 5,8-disubstituted indolizidine 235B (1), isolated from Dendrobates pumilio, acted as a potent noncompetitive and selective blocker of a4b2 nicotinic… (More)