Chelation of intracellular zinc triggers apoptosis in mature thymocytes.

  title={Chelation of intracellular zinc triggers apoptosis in mature thymocytes.},
  author={Mark J. McCabe and S. Anna Jiang and Sten Orrenius},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={69 1},
BACKGROUND Thymocyte apoptosis has been shown to be regulated by intracellular levels of cations. Elevation of [Ca2+]i can induce cell death by apoptosis, whereas, Zn2+ prevents it. EXPERIMENTAL DESIGN A membrane permeable metal ion chelator, N,N,N'N',-tetrakis (2-pyridylmethyl)ethylenediamine (TPEN), was used to examine the role of intracellular zinc in thymocyte (rat and human) apoptosis. Characteristics of apoptosis that were assessed included: chromatin degradation into oligosomal-sized… CONTINUE READING
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