Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

@article{Eberhard2009ChelationOI,
  title={Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.},
  author={Yanina Eberhard and Sean P. McDermott and Xiaoming Wang and Marcela Gronda and Amudha L Venugopal and Tabitha E. Wood and Rose Hurren and Alessandro Datti and Robert T Batey and Jeffrey L. Wrana and William E. Antholine and John E Dick and Aaron David Schimmer},
  journal={Blood},
  year={2009},
  volume={114 14},
  pages={3064-73}
}
Off-patent drugs with previously unrecognized anticancer activity could be rapidly repurposed for this new indication. To identify such compounds, we conducted 2 independent cell-based chemical screens and identified the antimicrobial ciclopirox olamine (CPX) in both screens. CPX decreased cell growth and viability of malignant leukemia, myeloma, and solid tumor cell lines as well as primary AML patient samples at low-micromolar concentrations that appear pharmacologically achievable… CONTINUE READING

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