Chelation Treatment for Autism Spectrum Disorders: A Systematic Review.

@article{Davis2013ChelationTF,
  title={Chelation Treatment for Autism Spectrum Disorders: A Systematic Review.},
  author={Tonya N Davis and Mark F. O'Reilly and Soyeon Kang and Russell B. Lang and Mandy Jenkins Rispoli and Jeff Sigafoos and Giulio E. Lancioni and Daelynn Copeland and Shanna Attai and Austin Mulloy},
  journal={Research in Autism Spectrum Disorders},
  year={2013},
  volume={7},
  pages={49-55}
}
Abstract Chelation treatment is used to eliminate specific metals from the body, such as mercury. It has been hypothesized that mercury poisoning may be a factor in autism and data suggest that perhaps 7% of individuals with autism spectrum disorder (ASD) have received chelation treatment. It would therefore seem timely to review studies investigating the effects of chelation treatment for individuals with ASD. To this end, we conducted a systematic search to identify studies that have… Expand

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References

SHOWING 1-10 OF 41 REFERENCES
Gluten-free and casein-free diets in the treatment of autism spectrum disorders: a systematic review
TLDR
Critical analysis of each study's methodological rigor and results reveal that the current corpus of research does not support the use of GFCF diets in the treatment of ASD. Expand
Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part B - Behavioral results
TLDR
Overall, both one and seven rounds of DMSA therapy seems to be reasonably safe in children with ASD who have high urinary excretion of toxic metals, and possibly helpful in reducing some of the symptoms of autism in those children. Expand
A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders.
TLDR
This study provides the first clinical evidence for the benefit that combined anti-androgen and anti-heavy metal therapy may have on some children with ASDs. Expand
Thimerosal-Containing Vaccines and Autistic Spectrum Disorder: A Critical Review of Published Original Data
TLDR
Evidence does not support a change in the standard of practice with regard to administration of thimerosal-containing vaccines in areas of the world where they are used, and the pharmacokinetics of ethylmercury make such an association less likely. Expand
Thimerosal-Containing Vaccines and Autistic Spectrum Disorder: A Critical Review of Published Original Data
TLDR
Evidence does not support a change in the standard of practice with regard to administration of thimerosal-containing vaccines in areas of the world where they are used, and the pharmacokinetics of ethylmercury make such an association less likely. Expand
Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results
TLDR
The Phase 1 single round of DMSA led to a dramatic normalization of RBC glutathione in almost all cases, and greatly improved abnormal platelet counts, suggesting a significant decrease in inflammation. Expand
A comprehensive approach to treating autism and attention-deficit hyperactivity disorder: a prepilot study.
TLDR
All 10 children showed significant improvement in many areas of social interaction, concentration, writing, language, and behavior, and Urinary lead burden dropped significantly in all 10 children. Expand
Mercury exposure: evaluation and intervention the inappropriate use of chelating agents in the diagnosis and treatment of putative mercury poisoning.
TLDR
The physician must be able to recognize the clinical manifestations of mercury intoxication, and understand the importance of biological markers in making a definitive diagnosis of mercury poisoning, in a desire to treat the patient complaining of symptoms similar to some that can be caused by mercury. Expand
Blood Mercury Concentrations in CHARGE Study Children with and without Autism
TLDR
Total Hg in blood was neither elevated nor reduced in CHARGE Study preschoolers with AU/ASD compared with unaffected controls, and resembled those of nationally representative samples. Expand
Succimer Chelation Improves Learning, Attention, and Arousal Regulation in Lead-Exposed Rats but Produces Lasting Cognitive Impairment in the Absence of Lead Exposure
TLDR
It is suggested that it may be possible to identify a succimer treatment protocol that improves cognitive outcomes in Pb-exposed children, however, it is also suggested that succencer treatment should be strongly discouraged for children who do not have elevated tissue levels of Pb or other heavy metals. Expand
...
1
2
3
4
5
...