Chelating Polymers for Hereditary Hemochromatosis Treatment.

@article{Groborz2020ChelatingPF,
  title={Chelating Polymers for Hereditary Hemochromatosis Treatment.},
  author={Ondřej Groborz and Lenka Poľakov{\'a} and Krist{\'y}na Kolouchov{\'a} and Pavel {\vS}vec and Lenka Loukotov{\'a} and Vijay Madhav Miriyala and Pavla Francov{\'a} and Jan Ku{\vc}ka and Jan Krijt and Petr P{\'a}ral and Martin B{\'a}je{\vc}n{\'y} and Tom{\'a}{\vs} Heizer and Radek Pohl and David Scott Dunlop and Jiř{\'i} Czernek and Luděk {\vS}efc and Jiř{\'i} Bene{\vs} and Petr {\vS}těp{\'a}nek and Pavel Hobza and Martin Hrub{\'y}},
  journal={Macromolecular bioscience},
  year={2020},
  pages={
          e2000254
        }
}
Hemochromatosis (iron overload) encompasses a group of diseases that are characterized by a toxic hyperaccumulation of iron in parenchymal organs. Currently, only few treatments for this disease have been approved; however, all these treatments possess severe side effects. In this study, a paradigm for hemochromatosis maintenance/preventive therapy is investigated: polymers with negligible systemic biological availability form stable complexes with iron ions in the gastrointestinal tract, which… 

Chelators for Treatment of Iron and Copper Overload: Shift from Low-Molecular-Weight Compounds to Polymers

Critical evaluation of this new perspective polymer approach, which shows vivid potential to keep the therapeutic efficacy of low-molecular-weight agents, while avoiding their drawbacks, especially their side effects, is the purpose of this review article.

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  • Jia Ji-don
  • Medicine, Biology
    Journal of hepatology
  • 2010
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