Chelatable iron and copper can be released from extracorporeally circulated blood during cardiopulmonary bypass.

@article{Moat1993ChelatableIA,
  title={Chelatable iron and copper can be released from extracorporeally circulated blood during cardiopulmonary bypass.},
  author={Neil E. Moat and Todd E Evans and Gregory J. Quinlan and John M C Gutteridge},
  journal={FEBS letters},
  year={1993},
  volume={328 1-2},
  pages={103-6}
}
During cardiopulmonary bypass surgery blood is extracorporeally oxygenated and circulated before returning to the systemic arterial circulation. Blood undergoing extracorporeal dilution and circulation is exposed to non-physiological surfaces, which cause the activation of several regulatory cascades. Cells are also subjected to damaging shear stresses. Under such conditions neutrophils can be 'activated' to release reactive oxygen intermediates such as O2- and H2O2, and other cells can release… CONTINUE READING

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