Checks and Balances in Neuromodulation

  title={Checks and Balances in Neuromodulation},
  author={Ronald M. Harris-Warrick and Bruce A. Johnson},
  booktitle={Front. Behav. Neurosci.},
Neuromodulators such as monoamines and peptides play important roles in activating and reconfiguring neural networks to allow behavioral flexibility. While the net effects of a neuromodulator change the network in a particular direction, careful studies of modulatory effects reveal multiple cases where a neuromodulator will activate functionally opposing mechanisms on a single neuron or synapse. This review gives examples of such opposing actions, focusing on the lobster pyloric network, and… CONTINUE READING

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