Checkpoints: How to Flag Up Double-Strand Breaks


How checkpoint pathways recognise double-strand breaks has long been a mystery. Recent studies have found that two distinct checkpoint protein complexes associate independently with chromatin at the sites of DNA damage. Why do two distinct mechanisms recognise strand lesions, and what does this tell us about the checkpoint pathways? 
DOI: 10.1016/S0960-9822(02)00673-5


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@article{Caspari2002CheckpointsHT, title={Checkpoints: How to Flag Up Double-Strand Breaks}, author={Thomas Caspari and Antony M. Carr}, journal={Current Biology}, year={2002}, volume={12}, pages={R105-R107} }