Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae

@article{Enserink2006CheckpointPC,
  title={Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae},
  author={Jorrit M. Enserink and Marcus Bustamante Smolka and Huilin Zhou and Richard D Kolodner},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={175},
  pages={729 - 741}
}
In response to DNA replication stress in Saccharomyces cerevisiae, the DNA replication checkpoint maintains replication fork stability, prevents precocious chromosome segregation, and causes cells to arrest as large-budded cells. The checkpoint kinases Mec1 and Rad53 act in this checkpoint. Treatment of mec1 or rad53Delta mutants with replication inhibitors results in replication fork collapse and inappropriate partitioning of partially replicated chromosomes, leading to cell death. We describe… CONTINUE READING

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