Checkpoint Inhibitors: Applications for Autoimmunity.

Abstract

To limit excessive T cell-mediated inflammatory responses, the immune system has a milieu of inhibitory receptors, called immune checkpoints. Cancer cells have evolved to seize those inhibitory pathways and to prevent T cell-mediated killing of tumor cells. Therefore, immune checkpoint inhibitors (ICI) consisting of blocking antibodies against these… (More)
DOI: 10.1007/s11882-017-0740-z

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