Checking on DNA damage in S phase

@article{Bartek2004CheckingOD,
  title={Checking on DNA damage in S phase},
  author={Jiri Bartek and Claudia Lukas and Jiri Lukas},
  journal={Nature Reviews Molecular Cell Biology},
  year={2004},
  volume={5},
  pages={792-804}
}
The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and… 
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