Checking on DNA damage in S phase

  title={Checking on DNA damage in S phase},
  author={Jiri Bartek and Claudia Lukas and Jiri Lukas},
  journal={Nature Reviews Molecular Cell Biology},
The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and… 
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The mechanisms regulating entry into and progression through S phase in eukaryotic cells are discussed and the main molecular players and mechanisms are introduced.
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Pathways governing G1/S transition and their response to DNA damage
Molecular views of recombination proteins and their control
  • S. West
  • Biology
    Nature Reviews Molecular Cell Biology
  • 2003
The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome stability and cell survival, especially in replicating cells, in which it plays a major role in tumour avoidance.
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These results identify specific degradation of Cdc25A as part of the DNA damage checkpoint mechanism and suggest how CDC25A overexpression in human cancers might contribute to tumorigenesis.
ATM and related protein kinases: safeguarding genome integrity
Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers.
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