Checking Your Breaks: Surveillance Mechanisms of Meiotic Recombination

@article{Hochwagen2006CheckingYB,
  title={Checking Your Breaks: Surveillance Mechanisms of Meiotic Recombination},
  author={Andreas Hochwagen and Angelika Amon},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={R217-R228}
}
Numerous DNA double-strand breaks (DSBs) are introduced into the genome in the course of meiotic recombination. This poses a significant hazard to the genomic integrity of the cell. Studies in a number of organisms have unveiled the existence of surveillance mechanisms or checkpoints that couple the formation and repair of DSBs to cell cycle progression. Through these mechanisms, aberrant meiocytes are delayed in their meiotic progression, thereby facilitating repair of meiotic DSBs, or are… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 98 CITATIONS, ESTIMATED 84% COVERAGE

Regulation of Hop1 function by Mec1/Tel1 phosphorylation

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Meiotic Dna Re-Replication And The Recombination Checkpoint

VIEW 15 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM

  • Chromosome Research
  • 2007
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2006
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 134 REFERENCES

The pachytene checkpoint.

  • Trends in genetics : TIG
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL