Chebulin: Terminalia chebula Retz. fruit-derived peptide with angiotensin-I-converting enzyme inhibitory activity.

@article{Sornwatana2015ChebulinTC,
  title={Chebulin: Terminalia chebula Retz. fruit-derived peptide with angiotensin-I-converting enzyme inhibitory activity.},
  author={Thakorn Sornwatana and Kunan Bangphoomi and Sittiruk Roytrakul and Nuanchawee Wetprasit and Kiattawee Choowongkomon and Sunanta Ratanapo},
  journal={Biotechnology and applied biochemistry},
  year={2015},
  volume={62 6},
  pages={746-53}
}
Angiotensin-I-converting enzyme (ACE) plays an important role in blood pressure regulation. In this study, an ACE-hexapeptide inhibitor (Asp-Glu-Asn-Ser-Lys-Phe) designated as chebulin was produced from the fruit protein of Terminalia chebula Retz. by pepsin digestion, ultrafiltrated through a 3 KDa cut-off membrane, a reverse-phase high-performance liquid chromatography, and nano-liquid chromatography tandem mass spectrometry analysis. Chebulin was found to inhibit ACE in a noncompetitive… CONTINUE READING