Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

@inproceedings{Durak2016Chd8MC,
  title={Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling},
  author={Omer Durak and Fan Gao and Yea Jin Kaeser-Woo and Richard Rueda and Anthony J. Martorell and Alexi Nott and Carol Y. Liu and Lindsay A. Watson and Li-Huei Tsai},
  booktitle={Nature Neuroscience},
  year={2016}
}
De novo mutations in CHD8 are strongly associated with autism spectrum disorder, but the basic biology of CHD8 remains poorly understood. Here we report that Chd8 knockdown during cortical development results in defective neural progenitor proliferation and differentiation that ultimately manifests in abnormal neuronal morphology and behaviors in adult mice. Transcriptome analysis revealed that while Chd8 stimulates the transcription of cell cycle genes, it also precludes the induction of… CONTINUE READING
25 Citations
58 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…