Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle

@article{Miller1985CharybdotoxinAP,
  title={Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle},
  author={Christopher Miller and Edward G. Moczydlowski and Ram{\'o}n Latorre and Marcia Phillips},
  journal={Nature},
  year={1985},
  volume={313},
  pages={316-318}
}
The recent development of techniques for recording currents through single ionic channels1 has led to the identification of a K+-specific channel that is activated by cytoplasmic Ca2+ (refs 2–12). The channel has complex properties, being activated by depolarizing voltages and having a voltage-sensitivity that is modulated by cytoplasmic Ca2+ levels. The conduction behaviour of the channel is also unusual, its high ionic selectivity being displayed simultaneously with a very high unitary… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 191 extracted citations

Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 4 Excerpts
Highly Influenced

Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma

Journal of the Association for Research in Otolaryngology • 2018
View 1 Excerpt

Change in plasma membrane potential of rat thymocytes by tert-butylhydroquinone, a food additive: Possible risk on lymphocytes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2017

Similar Papers

Loading similar papers…