Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle

  title={Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle},
  author={Christopher Miller and Edward G. Moczydlowski and Ram{\'o}n Latorre and Marcia Phillips},
The recent development of techniques for recording currents through single ionic channels1 has led to the identification of a K+-specific channel that is activated by cytoplasmic Ca2+ (refs 2–12). The channel has complex properties, being activated by depolarizing voltages and having a voltage-sensitivity that is modulated by cytoplasmic Ca2+ levels. The conduction behaviour of the channel is also unusual, its high ionic selectivity being displayed simultaneously with a very high unitary… CONTINUE READING

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