Charting the molecular network of the drug target Bcr-Abl.

  title={Charting the molecular network of the drug target Bcr-Abl.},
  author={Marc Brehme and Oliver Hantschel and Jacques Colinge and Ines Kaupe and Melanie Planyavsky and Thomas K{\"o}cher and Karl Mechtler and Keiryn L. Bennett and Giulio Superti-Furga},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 18},
The tyrosine kinase Bcr-Abl causes chronic myeloid leukemia and is the cognate target of tyrosine kinase inhibitors like imatinib. We have charted the protein-protein interaction network of Bcr-Abl by a 2-pronged approach. Using a monoclonal antibody we have first purified endogenous Bcr-Abl protein complexes from the CML K562 cell line and characterized the set of most tightly-associated interactors by MS. Nine interactors were subsequently subjected to tandem affinity purifications/MS… CONTINUE READING
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The chemokine IL - 8 and the surface activation protein CD 69 are markers for Bcr - Abl activity in CML

  • O Hantschel
  • Molecular Oncology
  • 2008

The chemokine IL-8 and the surface activation protein CD69 are markers for Bcr-Abl activity in CML. Molecular Oncology 2(3):272–281

  • O Hantschel
  • Brehme et al. PNAS May
  • 2008
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