Charting the NF-κB Pathway Interactome Map

  title={Charting the NF-κB Pathway Interactome Map},
  author={Paolo Tieri and Alberto Termanini and Elena Bellavista and Stefano Salvioli and Miriam Capri and Claudio Franceschi},
  booktitle={PloS one},
Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor κB (NF-κB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-κB activation, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon… CONTINUE READING
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