Charming neighborhoods on the cell surface: plasma membrane microdomains regulate receptor tyrosine kinase signaling.

@article{Santos2015CharmingNO,
  title={Charming neighborhoods on the cell surface: plasma membrane microdomains regulate receptor tyrosine kinase signaling.},
  author={Ralph Christian Delos Santos and Camilo Garay and Costin N Antonescu},
  journal={Cellular signalling},
  year={2015},
  volume={27 10},
  pages={1963-76}
}
Receptor tyrosine kinases (RTK) are an important family of growth factor and hormone receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the plasma membrane elicits activation of many signaling intermediates. The spatial and temporal regulation of RTK signaling within cells is an important determinant of receptor signaling… CONTINUE READING