Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal.

@article{Wolff2010ChargedRI,
  title={Charged residues in the C-terminus of the P2Y1 receptor constitute a basolateral-sorting signal.},
  author={Samuel C. Wolff and A D Qi and T. Kendall Harden and Robert A Nicholas},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 14},
  pages={2512-20}
}
The P2Y(1) receptor is localized to the basolateral membrane of polarized Madin-Darby canine kidney (MDCK) cells. In the present study, we identified a 25-residue region within the C-terminal tail (C-tail) of the P2Y(1) receptor that directs basolateral sorting. Deletion of this sorting signal caused redirection of the receptor to the apical membrane, indicating that the region from the N-terminus to transmembrane domain 7 (TM7) contains an apical-sorting signal that is overridden by a dominant… CONTINUE READING

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