Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression.

@article{Hawtin2006ChargedER,
  title={Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression.},
  author={Stuart R Hawtin and John Simms and Matthew T Conner and Zoe Lawson and Rosemary A. Parslow and Julie E Trim and Andrew Sheppard and Mark Wheatley},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 50},
  pages={38478-88}
}
For G-protein-coupled receptors (GPCRs) in general, the roles of extracellular residues are not well defined compared with residues in transmembrane helices (TMs). Nevertheless, extracellular residues are important for various functions in both peptide-GPCRs and amine-GPCRs. In this study, the V(1a) vasopressin receptor was used to systematically investigate the role of extracellular charged residues that are highly conserved throughout a subfamily of peptide-GPCRs, using a combination of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.

hp://w w w .jb.org/ D

  • Y. Cheng, W. H. Prusoff
  • Biochem. Pharmacol. 22,
  • 1973

Similar Papers

Loading similar papers…