Charged assembly helix motif in murine leukemia virus capsid: an important region for virus assembly and particle size determination.

@article{Cheslock2003ChargedAH,
  title={Charged assembly helix motif in murine leukemia virus capsid: an important region for virus assembly and particle size determination.},
  author={Sara Rasmussen Cheslock and Dexter T K Poon and William Fu and Terence D Rhodes and Louis E. Henderson and Kunio Nagashima and Connor F McGrath and Wei-Shau Hu},
  journal={Journal of virology},
  year={2003},
  volume={77 12},
  pages={7058-66}
}
We have identified a region near the C terminus of capsid (CA) of murine leukemia virus (MLV) that contains many charged residues. This motif is conserved in various lengths in most MLV-like viruses. One exception is that spleen necrosis virus (SNV) does not contain a well-defined domain of charged residues. When 33 amino acids of the MLV motif were deleted to mimic SNV CA, the resulting mutant produced drastically reduced amounts of virions and the virions were noninfectious. Furthermore… CONTINUE READING
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