Charge state of the globular histone core controls stability of the nucleosome.

@article{Fenley2010ChargeSO,
  title={Charge state of the globular histone core controls stability of the nucleosome.},
  author={Andrew T. Fenley and David A. Adams and Alexey V Onufriev},
  journal={Biophysical journal},
  year={2010},
  volume={99 5},
  pages={1577-85}
}
Presented here is a quantitative model of the wrapping and unwrapping of the DNA around the histone core of the nucleosome that suggests a mechanism by which this transition can be controlled: alteration of the charge state of the globular histone core. The mechanism is relevant to several classes of posttranslational modifications such as histone acetylation and phosphorylation; several specific scenarios consistent with recent in vivo experiments are considered. The model integrates a… CONTINUE READING