Characterizing the spatio-temporal role of sorting nexin 17 in human papillomavirus trafficking.

  title={Characterizing the spatio-temporal role of sorting nexin 17 in human papillomavirus trafficking.},
  author={Martina Bergant and {\vS}pela Peternel and David Pim and Justyna Karolina Broniarczyk and Lawrence Banks},
  journal={The Journal of general virology},
  volume={98 4},
The human papillomavirus (HPV) L2 capsid protein plays an essential role during the early stages of viral infection. Previous studies have shown that the interaction between HPV L2 and endosomal sorting nexin 17 (SNX17) is conserved across multiple PV types where it plays an essential role in infectious entry, suggesting an evolutionarily conserved pathway of PV trafficking. Here we show that the peak time of interaction between HPV-16 L2 and SNX17 is rather early, at 2 h post-infection… 

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