Characterizing the persistent CA3 interneuronal spiking activity in elevated extracellular potassium in the young rat hippocampus.

@article{Shin2010CharacterizingTP,
  title={Characterizing the persistent CA3 interneuronal spiking activity in elevated extracellular potassium in the young rat hippocampus.},
  author={Damian Seung-ho Shin and Wilson Yu and Adrian Fawcett and Peter L. Carlen},
  journal={Brain research},
  year={2010},
  volume={1331},
  pages={39-50}
}
Seizures coincide with an increase in extracellular potassium concentrations [K(+)](e) yet little information is available regarding this phenomenon on the firing pattern, frequency and neuronal properties of inhibitory neurons responsible for modulating network excitability. Therefore, we investigated the effects of elevating [K(+)](e) from 2.5 to 12.5mM on CA3 rat hippocampal interneurons in vitro using whole-cell patch-clamp recordings. We found that the majority of interneurons (21/25) in… CONTINUE READING
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