Characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries.

@article{Desmeules2006CharacterizingTO,
  title={Characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries.},
  author={Patrice Desmeules and Patrick J Devine},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2006},
  volume={90 2},
  pages={500-9}
}
Cyclophosphamide (CPA) is reported to target dormant primordial ovarian follicles in rodents and humans. However, mechanistic studies are complicated due to the complex ovarian structure. We present here the characterization of the sensitivity of ovaries to CPA metabolites and the timing of morphological alterations induced by phosphoramide mustard (PM) in an in vitro system. Intact mouse ovaries (postnatal-day-4) were cultured in vitro and exposed to multiple breakdown products of CPA on day 0… CONTINUE READING
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Endocrinology and toxicology: The female reproductive system

  • P. B. Hoyer, P. J. Devine
  • In Handbook of Toxicology, (M. J. Derelank,
  • 2002
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