Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals.

@article{Battle2014CharacterizingTG,
  title={Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals.},
  author={Alexis Battle and Sara Mostafavi and Xiao-wei Zhu and James B. Potash and Myrna M. Weissman and Courtney N. McCormick and Christian D. Haudenschild and Kenneth Beckman and Jianxin Shi and Rui Mei and Alexander E. Urban and Stephen B. Montgomery and Douglas F. Levinson and Daphne Koller},
  journal={Genome research},
  year={2014},
  volume={24 1},
  pages={14-24}
}
Understanding the consequences of regulatory variation in the human genome remains a major challenge, with important implications for understanding gene regulation and interpreting the many disease-risk variants that fall outside of protein-coding regions. Here, we provide a direct window into the regulatory consequences of genetic variation by sequencing RNA from 922 genotyped individuals. We present a comprehensive description of the distribution of regulatory variation--by the specific… CONTINUE READING
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