Characterizing the function and structural organization of the 5′ tRNA-like motif within the hepatitis C virus quasispecies

María Pirón, Nerea Beguiristain, A Ferrer - Nadal, Encarnacion Martinez-Salas, J. Gonzalez - Gomez
Published 2005 in Nucleic acids research

Abstract

Hepatitis C virus (HCV) RNA is recognized and cleaved in vitro by RNase P enzyme near the AUG start codon. Because RNase P identifies transfer RNA (tRNA) precursors, it has been proposed that HCV RNA adopts structural similarities to tRNA. Here, we present experimental evidence of RNase P sensitivity conservation in natural RNA variant sequences, including… (More)

A. J. Lyons, J. R. Lytle, J. G omez, H. D. Robertson
Nucleic Acids Res.,
2001

Characterizing the function and structural organization of the 5′ tRNA-like motif within the hepatitis C virus quasispecies

Abstract

Topics

10 Figures and Tables

Cited By

Exploiting tRNAs to Boost Virulence.

Evolution of the Protein Synthesis Machinery and Its Regulation

Messenger RNAs bearing tRNA-like features exemplified by interferon alfa 5 mRNA

Inhibition of hepatitis C virus by an M1GS ribozyme derived from the catalytic RNA subunit of Escherichia coli RNase P

Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs

RNA Structural Elements of Hepatitis C Virus Controlling Viral RNA Translation and the Implications for Viral Pathogenesis

Palindromic-nucleotide substitutions (PNS) of hepatitis C virus genotypes 1 and 5a from South Africa.

Inhibition of gene expression by RNase P.

Relevance of RNA structure for the activity of picornavirus IRES elements.

New insights into internal ribosome entry site elements relevant for viral gene expression.

References

Catalytic RNase P RNA from Synechocystis sp. cleaves the hepatitis C virus RNA near the AUG start codon.

Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet.

Long-range RNA-RNA interaction between the 5' nontranslated region and the core-coding sequences of hepatitis C virus modulates the IRES-dependent translation.

Replication and IRES-dependent translation are both affected by core coding sequences in subgenomic GB virus B replicons.

Domains on the hepatitis C virus internal ribosome entry site for 40s subunit binding.

Identification of an essential pseudoknot in the putative downstream internal ribosome entry site in giardiavirus transcript.

RNase P: variations and uses.

Specific cleavage of hepatitis C virus RNA genome by human RNase P.

The influence of viral coding sequences on pestivirus IRES activity reveals further parallels with translation initiation in prokaryotes.

Hepatitis C virus internal ribosome entry site RNA contains a tertiary structural element in a functional domain of stem–loop II

Slides referencing similar topics

Characterizing the function and structural organization of the 5′ tRNA-like motif within the hepatitis C virus quasispecies

Abstract

Topics

10 Figures and Tables

Cited By

Exploiting tRNAs to Boost Virulence.

Evolution of the Protein Synthesis Machinery and Its Regulation

Messenger RNAs bearing tRNA-like features exemplified by interferon alfa 5 mRNA

Inhibition of hepatitis C virus by an M1GS ribozyme derived from the catalytic RNA subunit of Escherichia coli RNase P

Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs

RNA Structural Elements of Hepatitis C Virus Controlling Viral RNA Translation and the Implications for Viral Pathogenesis

Palindromic-nucleotide substitutions (PNS) of hepatitis C virus genotypes 1 and 5a from South Africa.

Inhibition of gene expression by RNase P.

Relevance of RNA structure for the activity of picornavirus IRES elements.

New insights into internal ribosome entry site elements relevant for viral gene expression.

References

Catalytic RNase P RNA from Synechocystis sp. cleaves the hepatitis C virus RNA near the AUG start codon.

Detection of tRNA-like structure through RNase P cleavage of viral internal ribosome entry site RNAs near the AUG start triplet.

Long-range RNA-RNA interaction between the 5' nontranslated region and the core-coding sequences of hepatitis C virus modulates the IRES-dependent translation.

Replication and IRES-dependent translation are both affected by core coding sequences in subgenomic GB virus B replicons.

Domains on the hepatitis C virus internal ribosome entry site for 40s subunit binding.

Identification of an essential pseudoknot in the putative downstream internal ribosome entry site in giardiavirus transcript.

RNase P: variations and uses.

Specific cleavage of hepatitis C virus RNA genome by human RNase P.

The influence of viral coding sequences on pestivirus IRES activity reveals further parallels with translation initiation in prokaryotes.

Hepatitis C virus internal ribosome entry site RNA contains a tertiary structural element in a functional domain of stem–loop II

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